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Trimethoprim sulfa, a combination antibiotic that is commonly used in veterinary medicine, has been associated with causing keratoconjunctivitis sicca (KCS) in dogs. KCS, also known as dry eye, occurs when there is insufficient tear production, leading to dryness and inflammation of the conjunctiva and cornea. The exact mechanism by which trimethoprim sulfa induces KCS is not fully understood, but it is believed to involve its influence on the lacrimal glands.

Awareness of this potential side effect is important for veterinary practitioners when prescribing medications, especially for dogs that may already be predisposed to eye issues. Regular monitoring and client education about the signs of dry eye can help manage the risk associated with this drug.

The other drugs listed do not have the same well-documented association with KCS. Amitraz is primarily used as a topical antiparasitic agent and is not known to directly affect tear production. Griseofulvin is an antifungal medication that can have other side effects, but KCS is not commonly reported. Prednisolone, a corticosteroid, may even have anti-inflammatory effects on the eye, rather than cause dryness. Therefore, the link between trimethoprim sulfa